The Breakthrough (Netflix) Cast, Release Date, Wiki and More

Netflix’s The Breakthrough is a gripping, emotional drama inspired by true events. The story explores the moral, ethical, and emotional challenges faced by scientists and patients alike during a groundbreaking medical experiment. Combining powerful storytelling, nuanced performances, and thought-provoking themes, The Breakthrough delves into the high-stakes world of scientific discovery and its impact on humanity.

The Breakthrough


Is It Based on a Real Story?

Yes, The Breakthrough draws inspiration from real-life events. The film is loosely based on the journey of a revolutionary gene-editing treatment that sparked both hope and controversy in the scientific and medical communities. While some characters and events are fictionalized for dramatic effect, the core themes reflect genuine ethical dilemmas and personal struggles surrounding experimental medicine.


Cast & Characters

Main Cast:

  • Jesse Plemons as Dr. Gregory Hartman:
    A visionary scientist leading the groundbreaking research. Plemons delivers a riveting performance as a man torn between ambition and ethical responsibility.
  • Amanda Seyfried as Dr. Emily Carter:
    A compassionate physician working closely with patients. Seyfried portrays the emotional and ethical conflicts of being part of such a controversial project.
  • Regina King as Senator Angela Ward:
    A powerful politician advocating for transparency and ethical oversight in scientific innovation. King’s performance brings gravitas and determination to the role.
  • Paul Mescal as Adam Davis:
    A young, terminally ill patient who becomes the first to undergo the experimental treatment. Mescal portrays the vulnerability and courage of someone willing to risk everything for a second chance.
  • Bryce Dallas Howard as Rachel Hartman:
    Dr. Hartman’s supportive yet conflicted wife, navigating her role as both a partner and critic of her husband’s work.

Supporting Cast:

  • Stephen Root as Dr. Harold Weiss: A rival scientist skeptical of Dr. Hartman’s methods.
  • Anya Taylor-Joy as Lucy Adams: A determined journalist seeking the truth behind the medical breakthrough.
  • Lakeith Stanfield as Michael Bennett: A whistleblower with insider knowledge about the experiment.
  • John Lithgow as Chairman Richard Vaughn: The head of a pharmaceutical company funding the project, with hidden motives.
  • Florence Pugh as Sarah Bennett: A nurse who becomes emotionally invested in Adam’s journey.

Production Team

  • Director: Scott Derrickson (Doctor Strange, Sinister).
  • Screenwriter: C. Robert Cargill (The Black Phone, Sinister).
  • Producers:
    • Jason Blum (Blumhouse Productions).
    • Scott Derrickson and C. Robert Cargill.
  • Cinematographer: Mandy Walker (Elvis, Mulan).
  • Music Composer: Ludwig Göransson (Tenet, Black Panther).

Releasing Date

The Breakthrough is set to premiere globally on Netflix on 7th January 2025. The movie will be available for streaming in over 190 countries.


Why Watch?

  • Inspired by Real Events: A compelling narrative rooted in real-life breakthroughs in gene-editing science.
  • Stellar Cast: Features award-winning performances by Jesse Plemons, Amanda Seyfried, Regina King, and Paul Mescal.
  • Thought-Provoking Themes: Explores the intersection of ethics, ambition, and the human desire to overcome limitations.
  • Cinematic Excellence: Directed by Scott Derrickson and scored by Ludwig Göransson, promising an emotionally charged experience.

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